The accident took place on Highway 8, near the Natchez Trace, in Chickasaw County, Mississippi, on Thursday night.
State troopers said a car driven by 49-year-old Wilson Parker was backing out of a driveway right before the crash.
The other automobile involved was driven by 62-year-old Melvin Jackson of Aberdeen, who was eastbound on Highway 8.
An occupant in Parker’s car, 52-year-old Mabeline Vance of Houston, died at the scene.
Parker and 72-year-old Mattie Baskins have been injured. Jackson was not injured.
The Mississippi Highway Patrol continues to investigate the accident.