Two people were killed and five were injured after a two-car crash on the A53 Buxton Road in Leek, Staffordshire at about 16:30 BST on Monday.
Two drivers, both men, were pronounced dead at the scene.
A woman and boy from one of the cars were hospitalized over serious injuries.
After receiving advanced trauma care, a man was airlifted to hospital with serious injuries.
Two other victims, a man and a woman were also hospitalized but their injuries were less.