At least three were confirmed dead after tractor-trailers and other vehicles hit each other during a snow squall on an icy interstate in Pennsylvania on Monday.
More than a dozen were injured.
At least 50 vehicles were involved in the pileup.
The crash took place on Interstate 81. It was captured in videos posted on social media showing that drivers and passengers were lining the snowy road and jumping out as multiple vehicles crashed in less than a minute.
Officials confirmed three fatalities by afternoon but added that the number could increase.
Pennsylvania State Police was investigating the incident.
“This is crazy!” A driver captured the dramatic moments several vehicles piled up on a Pennsylvania highway during a snow squall on Monday. At least three people died from the collisions. https://t.co/Rl2oM1XIxo pic.twitter.com/TPONsgRAj0
— 48 Hours (@48hours) March 29, 2022