It was around 2 a.m. Sunday when officials responded to the area of Front Street Northeast and Division Street Northeast and saw a car that crashed into a homeless camp.
Two people were pronounced dead at the scene.
Four others from the homeless camp were admitted to the hospital with life-threatening injuries, and two succumbed to their injuries died.
Their identities were not released.
As of 8:55 a.m., all streets have opened in the area.
Salem Police Department said the traffic team is investigating the crash.