The accident took place on early Sunday morning in the 9500 block of Cypress Creek Parkway near Falcon Road.
The crash took place when a westbound vehicle tried to make a left-hand turn and collided with an eastbound tow truck.
Two passengers in the first vehicle were pronounced dead at the scene.
The driver of the westbound vehicle was taken to the hospital.
The driver of the tow truck was not harmed in the crash.